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Patrick F Smith Selected Research

danoprevir

1/2016Modelling the interaction between danoprevir and mericitabine in the treatment of chronic HCV infection.
5/2015Characterization of the transmembrane transport and absolute bioavailability of the HCV protease inhibitor danoprevir.
11/2013A randomised study of the effect of danoprevir/ritonavir or ritonavir on substrates of cytochrome P450 (CYP) 3A and 2C9 in chronic hepatitis C patients using a drug cocktail.
9/2013Pharmacokinetics of a three-way drug interaction between danoprevir, ritonavir and the organic anion transporting polypeptide (OATP) inhibitor ciclosporin.
8/2011Antiviral activity of danoprevir (ITMN-191/RG7227) in combination with pegylated interferon α-2a and ribavirin in patients with hepatitis C.
7/2011Danoprevir monotherapy decreases inflammatory markers in patients with chronic hepatitis C virus infection.
10/2010Oral combination therapy with a nucleoside polymerase inhibitor (RG7128) and danoprevir for chronic hepatitis C genotype 1 infection (INFORM-1): a randomised, double-blind, placebo-controlled, dose-escalation trial.

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Patrick F Smith Research Topics

Disease

11Infections
12/2020 - 01/2005
7Chronic Hepatitis C
12/2014 - 10/2010
7Neoplasms (Cancer)
02/2009 - 12/2003
4Human Influenza (Influenza)
01/2021 - 03/2016
3Inflammation (Inflammations)
01/2022 - 02/2007
3COVID-19
01/2021 - 01/2020
2Communicable Diseases (Infectious Diseases)
01/2021 - 10/2020
2Hepatitis C
02/2013 - 08/2011
2Diarrhea
02/2007 - 02/2006
1Liver Diseases (Liver Disease)
03/2022
1Respiratory Syncytial Virus Infections
01/2019
1Lung Neoplasms (Lung Cancer)
05/2015
1Breast Neoplasms (Breast Cancer)
05/2015
1Body Weight (Weight, Body)
08/2013
1Virus Diseases (Viral Diseases)
07/2011
1Esophageal Neoplasms (Esophageal Cancer)
02/2009
1Carcinoma (Carcinomatosis)
05/2007
1Weight Loss (Weight Reduction)
02/2007
1Opioid-Related Disorders (Opiate Addiction)
12/2006
1Cardiomyopathies (Cardiomyopathy)
05/2006
1Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
05/2006
1Chest Pain (Chest Pains)
05/2006
1Heart Diseases (Heart Disease)
05/2006
1Myocardial Infarction
05/2006
1Myocardial Ischemia (Ischemic Heart Diseases)
05/2006
1HIV Infections (HIV Infection)
03/2006
1Colonic Neoplasms (Colon Cancer)
02/2006
1Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
01/2006
1Acquired Immunodeficiency Syndrome (AIDS)
01/2005

Drug/Important Bio-Agent (IBA)

9Antiviral Agents (Antivirals)IBA
01/2021 - 10/2010
7danoprevirIBA
01/2016 - 10/2010
5Pharmaceutical PreparationsIBA
01/2021 - 05/2005
5Irinotecan (Camptosar)FDA LinkGeneric
08/2008 - 05/2005
4NucleosidesIBA
01/2019 - 01/2005
4Protease Inhibitors (Protease Inhibitor)IBA
07/2011 - 03/2006
3Oseltamivir (Tamiflu)FDA Link
01/2021 - 08/2013
3Ritonavir (Norvir)FDA Link
11/2013 - 12/2006
3InterferonsIBA
04/2012 - 10/2010
2Hemagglutinins (Hemagglutinin)IBA
12/2020 - 03/2016
2Monoclonal AntibodiesIBA
12/2020 - 03/2016
22'- fluoro- 2'- methyl- 3',5'- diisobutyryldeoxycytidineIBA
01/2016 - 10/2010
2Ribavirin (Virazole)FDA LinkGeneric
04/2012 - 08/2011
2RNA (Ribonucleic Acid)IBA
07/2011 - 10/2007
2Selenomethionine (Sethotope)FDA Link
08/2008 - 02/2006
2selenomethylselenocysteine (methylselenocysteine)IBA
05/2007 - 05/2005
1ALN-PCSIBA
03/2022
1Phosphotransferases (Kinase)IBA
01/2022
1Immunoglobulins (Immunoglobulin)IBA
12/2020
1Immunoglobulin G (IgG)IBA
12/2020
1ProdrugsIBA
01/2019
1oseltamivir carboxylateIBA
01/2017
1Broadly Neutralizing AntibodiesIBA
03/2016
1Proteins (Proteins, Gene)FDA Link
05/2015
1AnionsIBA
05/2015
1Member 1 Subfamily B ATP Binding Cassette TransporterIBA
05/2015
1Carrier Proteins (Binding Protein)IBA
05/2015
1Peptides (Polypeptides)IBA
05/2015
1Cytochrome P-450 CYP2C9IBA
11/2013
1Cytochrome P-450 Enzyme System (Cytochrome P450)IBA
11/2013
1Peptide Hydrolases (Proteases)FDA Link
09/2013
1InterleukinsIBA
04/2012
1Interferon LambdaIBA
04/2012
1Carboxylesterase (Hydrolase S)IBA
02/2009
1Capecitabine (Xeloda)FDA Link
02/2009
1Oxaliplatin (Eloxatin)FDA LinkGeneric
02/2009
1bevirimatIBA
10/2007
1SeleniumIBA
05/2007
1Cyclooxygenase 2 (Cyclooxygenase-2)IBA
02/2007
1Celecoxib (Celebrex)FDA Link
02/2007
1Buprenorphine (Subutex)FDA LinkGeneric
12/2006
1Nelfinavir (Viracept)FDA Link
12/2006
1LopinavirFDA Link
12/2006
1Opioid Analgesics (Opioids)IBA
12/2006
1GemcitabineFDA Link
05/2006
1Atazanavir Sulfate (Reyataz)FDA Link
03/2006
1Lansoprazole (Prevacid)FDA LinkGeneric
03/2006
1Proton Pump InhibitorsIBA
03/2006
1AnthracyclinesIBA
01/2006
1Cytarabine (Cytosar-U)FDA LinkGeneric
01/2006
1Type I DNA Topoisomerases (Topoisomerase I)IBA
01/2006
1AntimetabolitesIBA
01/2006
1trioctyl phosphine oxide (TOPO)IBA
01/2006
1Linezolid (Zyvox)FDA Link
07/2005
1quinupristin-dalfopristin (Synercid)FDA Link
07/2005
1DaptomycinFDA Link
07/2005
1FluoroquinolonesIBA
05/2005
1DNA Repair EnzymesIBA
05/2005
1Cytochrome P-450 CYP3AIBA
05/2005
1Fas Ligand Protein (Fas Ligand)IBA
05/2005
1Reverse Transcriptase InhibitorsIBA
01/2005
1Delavirdine (Rescriptor)FDA Link
01/2005
1Glutathione (Reduced Glutathione)IBA
12/2003
1Alkylating AgentsIBA
12/2003
1PlatinumIBA
12/2003

Therapy/Procedure

8Therapeutics
12/2020 - 01/2006
2Drug Therapy (Chemotherapy)
02/2007 - 05/2006
1Radiotherapy
02/2009